Is generic sildenafil as good as Viagra?

Nowadays a great variety of generic drugs is available on the market. They have the same active ingredient that is they have the same mechanism of action. The main difference is the price because generics are significantly cheaper without change in efficiency.

Viagra and its generic version Sildenafil based on the active ingredient sildenafil are oral drugs used for treating erectile dysfunction. They belong to the phosphodiesterase inhibitors (PDE-5 inhibitors). PDE5 is the enzyme regulates the blood flow in the penis. Medications of this class demonstrate their effect only in presence of a sexual stimulation.

The reason is that the effect of these drugs depends on the natural release of nitric oxide (NO), produced by the body only during the time of sexual arousal. Nitric oxide activates other substances to relax the smooth muscle of the penis to let the inflow of blood and this action leads to an erection. The effect of both Viagra and Sildenafil consists in intensifying the action of NO.

Approximately only 15% of persons taking Viagra or Sildenafil experience side effects. The most common of them are facial flushing, headaches, stomach pain, stuffy nose, dizziness, rash and in some rare cases they also include an inability to differentiate between green and blue colors.

Sildenafil is usually prescribed in dosage of 25 to 100 mg 1 hour before sexual activity. You cannot exceed the maximum dose of 100 mg per day.

People over the age of 65 should start with the dosage of 25 mg before sexual activity.

Absorption of sildenafil happens quickly. Maximum concentrations of this ingredient in the blood are experienced within 30 to 120 minutes (median 60 minutes) after taking in the fasted state.

A high fat meal may reduce the rate of absorption, postponing maximum concentration of the drug in the blood for an hour more.

Sildenafil may increase the effects of the blood pressure lowering medications. It also increases the blood pressure lowering effects of nitrates, for example, isosorbide mononitrate (Imdur, Ismo, Monoket), isosorbide dinitrate (Isordil),nitroglycerin (Nitro-Dur, Transderm-Nitro) which are usually prescribed for treating angina.

Cimetidine (Tagamet), atazanavir (Reyataz),erythromycin, itraconazole (Sporanox), ketoconazole (Nizoral),and mibefradil (Posicor) can cause marked increases in the amount of Viagra in the body.

If you are taking any of this medications, you must inform your doctor about it before starting treatment with Sildenafil.

Sildenafil also cannot be combined with other PDE5 inhibitors.